ABSTRACT
It is aimed to identify the basic success factors, which are essential for startups as they intend to develop successful and profitable business models over time. To this end, it is attempted to analyze the sentiments on user-generated content (UGC) on Twitter. First, trigram word cloud is used. Then, a sentiment analysis is done with various predictive models including random forest, support-vector machine (SVM) and multilayer perceptron (MLP) to test the labeling of unlabeled data. To divide topics into negative, positive, and neutral sentiments, latent Dirichlet allocation (LDA) has been applied. According to the results, the MLP method on the basis of accuracy criterion offers an accuracy of 0.81, which is higher than other tested methods. In this regard, random forest and SVM methods provide accuracy of 0.78 and 0.80, respectively. Voting and stacking algorithms were used to increase the accuracy of the algorithms. However, it is found that with the use of voting method, the accuracy is almost equal to the results obtained from the MLP and with stacking method the accuracy is less than all three methods. Using word cloud, it is indicated that the most negative trigram is startups innovation regarding climate change, the most positive one is product marketing management and business-related concepts are determined as neutral. It is found that startup acceleration process, pushing for quicker completion, delivering the best product at the beginning of the project, poor management practices, and focusing just on properties are grouped as negative sentiments. On the other hand, sustainable and innovative business plan, the presence of experienced entrepreneurs and investors, coronavirus (COVID-19), and innovation are recognized as positive sentiments, and no analysis is given for neutral sentiments. © The Author(s) 2022.
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Background: The large proportion of coronavirus disease 2019 (COVID-19) patients has been associated with a large number of neu-ropsychiatric manifestations. Despite the high prevalence of COVID-19, few studies have examined such manifestations, especially in children and adolescents. Objective(s): This study investigated neuropsychiatric manifestations in hospitalized children and adolescents admitted for COVID-19 infection in Iran. Method(s): This prospective observational study included admitted children and adolescents (4-18 years old) diagnosed with COVID-19 infection, pediatric neurologists, child and adolescent psychiatrists, and infectious disease specialists, and assessed 375 infected patients during August and December 2021. Result(s): Of the 375 patients, 176 (47%) were female, with a mean age of 9.0 +/- 3.39 years. Psychiatric and neurological manifestations were reported in 58 (15.5%) and 58 (15.5%) patients, respectively. The most prevalent psychiatric disorders were separation anxiety disorder (SAD) (5.1%), major depressive disorder (MDD) (3.5%), generalized anxiety disorder (GAD) (2.7%), insomnia (2.4%), and op-positional defiant disorder (ODD) (2.4%). Regarding neurological complications, seizures were the most prevalent (13.1%), followed by encephalitis (1.9%), transverse myelitis (0.3%), acute ischemic stroke (0.3%), and Guillain-Barre syndrome (0.3%). There was no significant relationship between the duration of COVID-19 infection (P = 0.54) and ICU admission (P = 0.44) with the emergence of psychiatric symptoms. Conclusion(s): The most prevalent neurologic and psychiatric complications among children and adolescents with COVID-19 infection were seizures and the symptoms of anxiety/mood disorders, respectively.Copyright © 2023, Author(s).
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In the actual worldwide context of manufacturing, the capacity to introduce, adapt and produce a new product quickly represents an important strategic objective. This is also a remarkable challenge for the managers, specifically due to the instability in demand and supply. COVID -19 and Russia-Ukraine war have amplified this instability. The flexibility in several parts of a manufacturing system is one of the main pillars of industry 4.0 and could be a great initiative to be investigated. However, there are several types of flexibility, and prioritizing them remains a difficult decision. The definition of several types of flexibility, the opportunity offered by each one, the complexity to implement them, and the way to evaluate their levels are not well developed in the literature. This paper proposes several types of flexibility, the challenges, and some key indicators to measure them. Then a model to identify the appropriate flexibility is proposed. To illustrate the complexity of the problem, a use case of launching a new product in the automotive industry is presented and the necessity to identify the appropriate flexibilities is discussed. © 2022 IEEE.
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Background: COVID-19 induced cardiac events are reported by many papers, while psychophysiology of association of the COVID-19 and cardiac attacks are not fully understood yet. Materials and Methods: Here, we compared gene expression levels of heart autopsies of SARS-Cov-2 infected patients with the cardiac organoid model of human myocardial infarction and controlled healthy cardiac organoids to identify differentially expressed genes (DEGs). Gene Ontology (GO) biological processes were enriched in DEGs.
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Background: Despite all of the research on the risk factors for severe COVID-19, there are still many unknowns about the course of COVID-19 in various populations. Inevitable exposure of dialysis patients, one of the more vulnerable groups for infectious diseases, to COVID-19 concerns many researchers. Furthermore, studies on the mortality rate and risk factors regarding dialysis patients are somewhat inconsistent. Also, it has been suggested that factors such as ethnicity can contribute to that matter. Objectives: We aimed to evaluate the mortality rate of dialysis patients who contracted COVID-19 in the Iranian population. Methods: In this cross-sectional study, we presented the experiences of 4 dialysis centers with a total of 309 dialysis patients (Tehran, Iran) during the COVID-19 pandemic to assess the mortality rate and associated risk factors. Results: Among 309 dialysis patients, 58 patients contracted the disease, and the total mortality rate in this study was 41%. It was observed that although the guidelines for screening patients were similar in these 4 centers, the centers with regular COVID-19 screening for staff members had much lower mortality and infection rate. The most common symptoms in patients were fever, dry cough, and chills. Furthermore, comorbidities such as diabetes can also increase the risk of mortality. Conclusions: This study, along with other studies, can be utilized in developing guidelines for dialysis centers in the COVID-19 pandemic and future pandemics.
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The COVID-19 pandemic has been transformed into one of the main worldwide chal-lenges, in recent years. For controlling symptoms that are caused by this disease (e.g., chills or fever, shortness of breath and/or difficulty in breathing, cough, sore throat, fatigue, headache, muscle aches, the new loss of tastes and/or smells, congestion or runny nose, nausea, vomiting and/or diar-rhea), lots of medicines including analgesics, mucolytics, and anti-biotic/viral/inflammatory drugs have been frequently prescribed. As these medicines finally contaminate terrestrial and aquatic hab-itats by entering surface waterways through pharmaceutical production and excreting trace amounts of waste after human usage, they have negative impacts on wildlife’s health and ecosys-tem. Residual drugs in water have the potential to harm aquatic creatures and disrupt their food chain as well as the breeding cycle. Therefore, proper degradation of these broadly used medicines is highly crucial. In this work, the use of nanomaterials applicable in photocatalytic degradations of analgesics (e.g., acetaminophen, aspirin, ibuprofen, and naproxen), mucolytics (e.g., ambroxol), antibiotics (e.g., azithromycin and quinolones including hydroxychloroquine and chloroquine phos-phate), anti-inflammatory glucocorticoids (e.g., dexamethasone and cortisone acetate), antihistamines (e.g., diphenhydramine), H2 blockers (e.g., famotidine), anthelmintics (e.g., praziquantel), and finally antivirals (e.g., ivermectin, acyclovir, lopinavir/ritonavir, favipiravir, nitazoxanide, and remdesivir) which widely used in controlling/treating the coronavirus have been reviewed and dis-cussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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Tuberculosis (TB) has infected billions of people worldwide. The clinical appearance of TB is close to that of Coronavirus disease 2019 (COVID-19). Active pulmonary TB infection can lead to severe pulmonary distress syndrome. Recent studies have revealed the clinical significance of TB surveillance in COVID-19 patients. In this mini-review, we compiled data from published literature and addressed the significance of interplay between TB and SARS-CoV-2 co-infection. Bilateral cross-relationship between these two major public health issues can be classified into two main categories. On one hand, active TB and multidrug-resistance infections lead to poor prognosis, particularly in elderly patients with COVID-19. On the other hand, the SARS-CoV-2 pandemic caused major harm to the global TB services and surveillance.
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Background and purpose: Coronavirus 2019 (COVID-19) is an infectious disease with a death rate of 1-5%. The aim of this study was to determine the relationship between spiritual health and the effects of grief from the loss of loved one due to COVID-19. Materials and methods: This cross-sectional study was performed in 312 family members of the deceased COVID-19 patients in Mashhad, Iran, April-September 2020. Non-randomized sampling was performed and data were collected online using the Grief Experience Questionnaire (GEQ-34) and the Spiritual Well Being Scale. Data were analyzed using descriptive tests and Pearson correlation coefficient. Results: According to findings, the highest score in dimensions of grief experience was found for the dimension of stigma (3.89±0.54), followed by the attempt to justify and cope with the absence of the deceased person (3.49±0.43), and judgment of the person or others about the cause of death (3.23±0.37). The highest relationship between spiritual health and reducing the effects of grief was seen in the dimensions of embarrassment and shame (r=-0.593), guilt (r=-0.566), and abandonment (r=-0.535). Conclusion: Abnormal grief in the family of deceased COVID-19 patients is common which could have a negative impact on physical, mental, social, and functional health. So, social support and strengthening spiritual health are needed to reduce the effects of grief in bereaved survivors.
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Introduction: COVID-19 is currently a global pandemic, and coagulation-related mortality has been widely reported in patients suffering from it. Objective: this article aimed to investigate the coagulation profile of COVID-19 patients. Methods: This was a cross-sectional study conducted using a retrospective research design. We recruited patients with COVID-19 admitted to a hospital from June 15th to July 7th, 2020. Upon patients’ entering a blood sample was drawn from each patient for assessing patient’s coagulation profile (PT, PTT, INR, Platelet count);and a chest high-resolution computed tomography (HRCT) scan was performed for each patient. The study patients were divided in to sever group (CO-RADS score 5) and non-sever group (CO-RADS score <5). Results: Thirty-six patients (20 males and 16 females) with a mean age of 54.7±17.5 years were studied. Of them, 11 cases (30.56%) had severe pulmonary involvement. Also, the coagulation profiles were longer in the severe group than non-sever group. As well, the means of platelet count that were 232.440 per microliter in the non-severe group and 289.180 per microliter in the severe and non-sever groups, respectively;but still not statistically significant (p>0.05). The Area under the ROC Curve (AUC) for PT and INR was 0.615 and 0.611, respectively. The AUC for platelet count was 0.680 (95% CI: 0.501 to 0.859) and had an acceptable discriminating power. Conclusions: In this study, we did not find any statistically significant relationship between the results of coagulation tests and the severity of pulmonary involvement according to HRCT scan findings in COVID-19 patients. But further analyses suggest that, except PTT, the other coagulation tests (PT, INR, and platelet count) may discriminate severe COVID-19 patients. © 2021 Tehran University of Medical Sciences.
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Background and purpose: Coronavirus 2019 (COVID-19) is an infectious disease with a death rate of 1-5%. The aim of this study was to determine the relationship between spiritual health and the effects of grief from the loss of loved one due to COVID-19. Materials and methods: This cross-sectional study was performed in 312 family members of the deceased COVID-19 patients in Mashhad, Iran, April-September 2020. Non-randomized sampling was performed and data were collected online using the Grief Experience Questionnaire (GEQ-34) and the Spiritual Well Being Scale. Data were analyzed using descriptive tests and Pearson correlation coefficient.
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The main aim of the present study is to disclose the similarities or differences of the climate effects on the COVID-19 outbreak in two countries, which have different climatic conditions. Using the correlation modeling, the results revealed that some climatic factors, such as the ULR, temperature, and CH4 in the UAE and aerosol index and NO2 in Switzerland have positive lagged correlations with the outburst of COVID-19 by intensifying role within - 9, - 7, and - 2 days. The mitigating role was also observed for ozone/solar radiation and temperature/long-wave radiation in the UAE and Switzerland, respectively. The initial hypotheses of the research have confirmed the correlations between new cases of COVID-19 and ULR and aerosol indices in the UAE and Switzerland. However, the main finding revealed that the climate effects on the COVID-19 outbreak show different roles in the different countries, locating in dissimilar climatic zones. Accordingly, the COVID-19 can be intensified by increases of the ULR and temperature in an arid region, while it can be exactly mitigated by increases of these factors in a temperate area. This finding may be useful for future researches for identifying the essential influencing factors for the mitigating COVID-19 outbreak.
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The present study aims to emphasize an empirical perspective on the global scope of the COVID-19 event. The focus is that of an investigator concerned with Iran’s security and specific services used to process civil interactions. Game Theory dynamics affect uncertainty, proxy wars and the complex geopolitics of the Middle East. This often requires key players to focus on security by any means at their disposal. The maintenance of Iran’s autonomy and political security all too often require opposition to circumstances and players even while under heavy sanctions. This study seeks to answer the following questions: 1. Was this event actually a threat from the west, specifically from the US? 2. Was there an internal criminal element operating in Iran? 3. What was the nature of Iran’s response politically and socially concerning the pandemic? These objectives initially concern scrutinizing the extent of terrorist or criminal violations identified by Western authorities regarding Iran’s hegemonic involvement, particularly in Iraq. Secondly, we examine impacts from the Coronavirus threat that changed Iran’s focus in response to the US politically, and on her ability to effectively manage the COVID-19 contagion internally. Thirdly, the epidemic’s effects on Iranians. The investigation draws on literature and facts to analyze these impacts. The pandemic threatened Iran’s social and political stability and served to further distance the government from its people. This is, therefore, treated as a serious condition with potentially exponential effects on national security. © Koninklijke Brill NV, Leiden, 2020.
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Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the leading cause of death since December 2019. The most common clinical manifestations are cough, fever, and dyspnea;however, non-specific findings are also reported. This virus affects all age groups with a predilection to the adults, but children and neonates can also be affected. Case Presentation: An 11-days-old male neonate was brought to the hospital with chief complaints of vomiting and severe watery diarrhea. All laboratory data, including the stool OB/OP test, were normal except for leukocytosis. His parents were asymptomatic. In the following, qRT-PCR from neonate’s nasopharynx reported positive. Supportive and symptomatic treatments were done. The neonate discharged from the hospital without any significant sequelae. Conclusions: Extrapulmonary manifestation of COVID-19, especially gastrointestinal findings, should be considered in neonates to avoid possible complications and further spread of the disease.